Amanda Anisimova defeated Kimberly Birrell 6–3, 6–2 in the first round of the US Open on hard court on 26 August 2025, confirming her status as the heavy pre-match favourite at odds of 1.18. Birrell, trading at 5.6, offered little resistance as Anisimova controlled proceedings throughout, breaking serve consistently and maintaining a commanding performance across both sets. The American's dominant display underscored her superiority in the matchup and suggests she enters the early rounds of the tournament with considerable momentum heading into the second round.