Amanda Anisimova defeated Mayar Sherif 6–2, 6–2 in the first round of the Miami Masters 1000 on hard court on 21 March 2025, confirming her status as the heavy pre-match favourite with odds of 1.12 to Sherif's 7.3. The American's dominant performance saw her progress through the opening round without significant resistance, dismantling her Egyptian opponent in straight sets with a commanding display. The decisive margin reflects Anisimova's clear superiority on the day and her readiness for the tournament's deeper stages. The result maintains Anisimova's momentum in the early season and positions her favourably for a potential run through Miami's competitive draw.