Amanda Anisimova defeated Yuliia Starodubtseva 6–4, 6–2 in the first round of the Miami Masters on hard court on 21 March 2026. As the heavy favourite at 1.10 odds, Anisimova delivered an expected performance against the substantial underdog Starodubtseva, who entered at 6.63. The American controlled the opening set before accelerating in the second to secure a convincing victory. The result maintains Anisimova's momentum at one of the season's premier hard-court events.