Ana Konjuh defeated Sara Errani 7–5, 6–2 in the first round of the WTA 250 Istanbul tournament on clay on 19 April 2021. Konjuh, the pre-match favourite at 1.74 odds, delivered a composed performance to advance, breaking down Errani's resistance in both sets. The Croatian secured the opening set in a competitive first-set tussle before dominating the second to seal a straight-sets victory. The result underscored Konjuh's stronger form on the surface at that stage of the season, positioning her favourably for the second round.