Andrey Rublev defeated Francisco Comesana 6–2, 6–3 in the second round of the Cincinnati Masters on hard court. The Russian produced a dominant performance, breaking serve multiple times to control both sets and advance with relative comfort. Comesana, competing at this level of competition, struggled to establish a foothold in the match and offered limited resistance to Rublev's aggressive baseline game. The victory sees Rublev progress to the quarter-finals of the ATP Masters 1000 event, where he will face a higher-seeded opponent.