Ashleigh Barty defeated Laura Siegemund 6–0, 7–5 in the Stuttgart WTA 250 round of 16 on clay on 21 April 2021, confirming her status as the overwhelming pre-match favourite with odds of 1.18 to Siegemund's 5.59. Barty's performance was commanding in the opening set, which she won without conceding a game, before Siegemund mounted a more competitive challenge in the second, though ultimately to no avail. The Australian's dominant display on the Stuttgart clay underscored her credentials as a leading contender in the tournament.