Barbora Krejčíková defeated Victoria Mboko 6–3, 6–2 in the first round of the US Open on hard court on 25 August 2025, producing a significant upset against the pre-match favourite. Despite Mboko entering as the odds-on favourite at 1.48, Krejčíková's superior court positioning and consistency proved decisive, as she controlled both sets and conceded only five games across the match. The Czech player's dominant performance suggests strong form heading into the second round, while Mboko's early exit from the Grand Slam marks a disappointing result for the favoured seed.