Bianca Andreescu defeated Harmony Tan 6–0, 3–6, 6–1 in the first round of the US Open on hard court on 29 August 2022. As the heavy favourite at odds of 1.17, Andreescu delivered the expected result, though not without resistance from her French opponent. Tan took the second set to level the match, but Andreescu regrouped decisively in the third, reasserting her control to secure a comfortable victory. The Canadian's dominant first and final sets underlined her superiority on the day, though Tan's competitive showing in the middle set suggested she was capable of troubling seeded players. Andreescu's convincing turnaround after dropping a set positions her favourably for the second round.