Daniil Medvedev defeated Reilly Opelka 3–6, 7–5, 6–1 in the second round of the ATP 250 Washington tournament on hard court on 23 July 2025, confirming his status as the pre-match favourite with odds of 1.31 to Opelka's 3.81. After losing the opening set, Medvedev seized control in the second, breaking serve to claim a tight contest before dominating the third to secure a commanding victory. The Russian's recovery from the first-set deficit demonstrated composure against a formidable opponent known for his serving prowess. Medvedev's progression to the next round strengthens his campaign in the American summer hard-court season.