Sofia Kenin defeated Daria Kasatkina 6–3, 7–6 in the Charleston WTA 250 round of 16 on clay on 3 April 2025, an upset victory against the pre-match favourite. Despite Kasatkina's status as the odds-on favourite at 1.75, Kenin claimed the opening set comfortably before forcing a tiebreak in the second, ultimately prevailing in a competitive encounter. The result represents a significant scalp for Kenin on the clay court circuit and signals improved form heading into the latter stages of the tournament.