Lesia Tsurenko defeated Elsa Jacquemot 7–5, 3–6, 6–1 in the first round of the US Open on hard court on 29 August 2023, confirming her status as pre-match favourite with odds of 1.29 to Jacquemot's 3.9. Tsurenko secured the opening set in a competitive first frame before Jacquemot levelled the match by taking the second, but the Ukrainian regained control decisively in the third to advance. The victory underscored Tsurenko's superiority on the day and her positioning as a seeded threat in the early rounds of the Grand Slam. Her progression sets up a second-round encounter against the winner of the corresponding qualifying bracket.