Jannik Sinner defeated Francisco Cerundolo 7–6, 6–3 in the Rome Masters round of 16 on clay on 15 May 2025, confirming his status as pre-match favourite with odds of 1.29 to Cerundolo's 4.0. Sinner's victory followed expectation, though Cerundolo pushed the Italian to a first-set tiebreak before Sinner asserted control in the second. The result underscores Sinner's continued dominance on the Italian clay swing as he progresses deeper into the tournament.