Kei Nishikori defeated Francisco Comesaña 6–4, 1–6, 7–5 at the Cincinnati Masters 1000 on hard court. The result represented an upset, as Comesaña entered as the pre-match favourite at 1.73 odds to Nishikori's 2.0. Nishikori's victory came despite a second-set capitulation, where Comesaña dominated 6–1 to level the match. The Japanese veteran regrouped decisively in the decider, securing the crucial break in the final set to claim a three-set win. The comeback demonstrates Nishikori's capacity to recover from adversity in Masters events, while Comesaña's failure to convert his favoured status suggests inconsistency in high-pressure situations.