Raphael Collignon defeated Francisco Comesana 7–5, 3–6, 7–6 in the Round of 16 at the ATP 250 Brussels event on hard court, confirming his status as the pre-match favourite with odds of 1.44 to Comesana's 2.72. The Belgian player navigated a competitive encounter that swung between the players across three sets, ultimately prevailing in a tight decider. Collignon's victory advances him deeper into the tournament and underscores his solid form on the hard courts in Brussels.