Lorenzo Musetti defeated Gijs Brouwer 6–7, 6–3, 6–4, 6–2 in the first round of the US Open on hard court on 30 August 2022, confirming pre-match expectations as the favoured player. Brouwer mounted early resistance, pushing Musetti to a tiebreak in the opening set, but the Italian recovered to control the match thereafter, winning three consecutive sets with increasing dominance. The result underscores Musetti's progression through the early rounds of the Grand Slam, maintaining momentum as he advanced deeper into the tournament.