Harmony Tan defeated Samantha Stosur 6–2, 6–1 in the first round of the WTA 250 event in Strasbourg on clay on 15 May 2022, confirming her status as the pre-match favourite with odds of 1.2 to Stosur's 5.2. Tan's dominant performance saw her control proceedings throughout, dropping just three games across two sets against the former Australian Open champion. The comprehensive victory demonstrated Tan's comfort on the surface and her ability to impose her game early in the tournament. The result underlined Tan's momentum heading into the latter stages of the clay-court season.