Jannik Sinner defeated fellow Italian Lorenzo Musetti 6–1, 6–4, 6–2 in the US Open quarter-final on hard court on 3 September 2025, delivering a commanding performance that confirmed his status as the tournament favourite. Sinner's dominant display allowed Musetti precious few opportunities, with the world number one controlling proceedings throughout all three sets. The result followed the pre-match odds, which heavily favoured Sinner at 1.05 against Musetti's 16.01. The emphatic nature of the victory—dropping only seven games across the match—underscores Sinner's relentless form at Flushing Meadows and his clear ascendancy in the head-to-head with his compatriot. Sinner advances to the semi-finals of the year's final Grand Slam.