Karolína Muchová defeated Venus Williams 6–3, 2–6, 6–1 in the first round of the US Open on hard court. As the heavy favourite with odds of 1.09, Muchová delivered as expected, taking the opening set convincingly before Williams mounted a brief second-set challenge. The Czech player reasserted control in the decider, dominating the final set to advance comfortably. The result underscores Muchová's current form on hard courts and her status among the tournament's seeded players, whilst Williams, competing at 44, faced the challenge of matching the pace of a top-ranked opponent on a demanding surface. Muchová's progression to the second round keeps her on track for a deep run in New York.