Lorenzo Musetti defeated fellow Italian Matteo Arnaldi 7–6, 4–6, 7–6, 6–3 in the first round of the Australian Open on hard court on 14 January 2025, confirming his status as pre-match favourite at odds of 1.6 to Arnaldi's 2.5. The match proved competitive through three sets, with both players claiming a tiebreak apiece before Musetti seized control in the fourth to secure passage to the second round. The result extends Musetti's head-to-head record against his compatriot and demonstrates his capability to navigate tight contests at Grand Slam level early in the season.