Novak Djoković defeated Lorenzo Musetti 6–4, 6–3 in the Australian Open quarter-final on hard court on 28 January 2026, confirming his status as pre-match favourite at odds of 1.31 to Musetti's 3.38. The Serbian top seed controlled the encounter with clinical efficiency, claiming both opening sets before Musetti mounted a brief recovery in the third, reaching 3–1 before Djoković closed out the match. The result represents a commanding performance by the defending champion, who continues his pursuit of another Grand Slam title at Melbourne Park.