Matteo Berrettini defeated Marcos Giron 6–7 7–6 6–1 in the first round of the Madrid Masters on clay on 26 April 2025, confirming his status as the pre-match favourite despite odds of 1.2 suggesting a clear expectation of his victory. The match proved competitive through two tiebreak-decided sets before Berrettini asserted control in the third, breaking Giron's resistance decisively. The Italian's ability to navigate a tight opening phase and then dominate the decider underscores his form on the Spanish clay. Berrettini's progression maintains his momentum in the Masters 1000 calendar.