Sebastian Baez defeated Thiago Monteiro 7–5, 3–6, 6–4 in the quarter-finals of the ATP 250 Santiago tournament on clay on 25 February 2022, confirming his status as the pre-match favourite with odds of 1.63 to Monteiro's 2.42. Baez claimed the opening set in a tight contest before Monteiro levelled by taking the second with relative comfort, but the Argentine regained control in the decider to secure his place in the semi-finals. The result extended Baez's run in Santiago and underlined his growing threat on the South American clay circuit.